ÐÓ°ÉÖ±²¥ was founded in 1848 in Clarksville, Tennessee. Originally known as the Masonic University of Tennessee, the institution was renamed Stewart College in 1850 in honor of its president, William M. Stewart. Under Stewart′s leadership in 1855,
control of the college passed to the Presbyterian Church. ÐÓ°ÉÖ±²¥â€™ remains affiliated with the Presbyterian Church. In 1875, the college added an undergraduate School of Theology and became Southwestern Presbyterian University. The School of Theology operated until 1917.
In 1925, president Charles Diehl led the move to the present campus in Memphis, Tennessee (the Clarksville campus would later become Austin Peay State University). At that time, the college shortened its name to Southwestern. In 1945, the college adopted the name Southwestern at Memphis, to distinguish itself from other colleges and 
universities containing the name "Southwestern."
Finally, in 1984, the college′s name was changed to ÐÓ°ÉÖ±²¥ to honor former college president, and Diehl′s successor, Peyton Nalle ÐÓ°ÉÖ±²¥. Since 1984, ÐÓ°ÉÖ±²¥ has grown from a regionally recognized institution to a nationally ranked liberal arts and sciences college. As enrollment has increased over the past 20 years, so has the proportion of students from outside Tennessee and the Southeast region.
Today, ÐÓ°ÉÖ±²¥ is consistently ranked among the nation’s top liberal arts and sciences colleges.